Buy SLU-PP-332 | Premium Research Peptide UK

Buy SLU-PP-332 in the UK – >99% Purity | ERR Pan-Agonist | Research Use Only

SLU-PP-332 is a potent synthetic ERR pan-agonist studied for its exercise-mimicking properties at the molecular level — buy SLU-PP-332 in the UK from Peptides Lab UK with HPLC-confirmed >99% purity, full Certificate of Analysis (COA), and fast UK dispatch for laboratory research use.

What is SLU-PP-332?

SLU-PP-332 is a synthetic small-molecule compound developed as a selective pan-ERR agonist, designed to activate all three Estrogen-Related Receptors — ERRα, ERRβ, and ERRγ — simultaneously. Originally developed at Washington University School of Medicine and Saint Louis University, it has rapidly become one of the most studied exercise mimetic compounds in metabolic and mitochondrial research.

In controlled laboratory models, SLU-PP-332 has been shown to activate the same molecular pathways triggered by sustained aerobic exercise — influencing mitochondrial biogenesis, fatty acid oxidation, energy expenditure, and skeletal muscle metabolism — making it a central compound of interest for researchers investigating obesity, metabolic syndrome, cardiovascular disease, and age-related decline.

Molecular Formula: C₂₄H₁₉N₃O₂S Purity: >99% (HPLC verified) Form: Lyophilised powder Storage: –20°C; dry, away from heat and light Solubility: DMSO, bacteriostatic water, or suitable laboratory-grade solvents Stability: Up to 24 months when stored correctly

How Does SLU-PP-332 Work?

SLU-PP-332 works by binding to and activating ERRα, ERRβ, and ERRγ — a family of orphan nuclear receptors that act as master regulators of mitochondrial gene expression and cellular energy balance.

When these receptors are activated in a research setting, a downstream cascade is triggered that closely resembles the cellular environment created during sustained aerobic exercise. Key mechanisms observed in pre-clinical research include:

• ERRα, ERRβ, and ERRγ activation — targeting the primary regulators of mitochondrial and metabolic gene expression, with highest potency at ERRα (EC₅₀ = 98 nM)
• PGC-1α upregulation — stimulating the so-called “exercise gene” that drives mitochondrial biogenesis
• Increased mitochondrial density — promoting the creation of new mitochondria within skeletal muscle cells, boosting cellular energy capacity
• Enhanced fatty acid oxidation — shifting cellular metabolism toward fat as a primary fuel source
• Improved oxidative metabolism — promoting efficient, oxygen-based energy production in muscle tissue
• Type IIa oxidative muscle fibre increases — promoting the development of endurance-associated fibre types in skeletal muscle models

What Does SLU-PP-332 Do in Research?

In pre-clinical laboratory models, SLU-PP-332 has demonstrated a range of metabolically significant effects that have made it one of the most in-demand research compounds from UK peptides suppliers today:

• Mimics aerobic exercise at a cellular level — activating the molecular pathways normally triggered by endurance training
• Stimulates fat metabolism — promotes lipid oxidation and reduces fat accumulation in obesity and metabolic disease models
• Increases mitochondrial efficiency — boosts the number and performance of mitochondria within muscle cells
• Enhances physical endurance markers — pre-clinical studies in rodent models demonstrated significantly improved running capacity, including running for 70% longer and 45% further compared to controls
• Supports cardiac muscle function — research has explored its role in cardiac energy metabolism, ejection fraction, and heart failure models
• Regulates glucose metabolism — studied for relevance in type 2 diabetes, insulin sensitivity, and metabolic syndrome research
• Potential in muscle atrophy models — emerging research has examined ERR activation via SLU-PP-332 in the context of age-related muscle decline and sedentary lifestyle models

What Do Studies Say About SLU-PP-332?

SLU-PP-332 is among the best-supported exercise mimetic compounds in recent pre-clinical literature:

• Billon C et al. (2023) — ACS Chemical Biology — The foundational study identifying SLU-PP-332 as a synthetic ERR pan-agonist. Demonstrated enhanced exercise endurance, increased oxidative skeletal muscle fibres, and an ERRα-dependent acute aerobic exercise genetic programme in mice. DOI: 10.1021/acschembio.2c00720
• Billon C et al. (2024) — Journal of Pharmacology and Experimental Therapeutics / PMC — Examined SLU-PP-332 in mouse models of obesity and metabolic syndrome, reporting increased energy expenditure, fatty acid oxidation, reduced fat mass accumulation, and improved insulin sensitivity. PMC: PMC10801787
• Xu et al. (2024) — Circulation — Investigated pan-ERR agonists including SLU-PP-332 in a pressure overload-induced heart failure model. Both SLU-PP-332 and SLU-PP-915 significantly improved ejection fraction, reduced fibrosis, and increased survival, with broad transcriptional activation of cardiac fatty acid metabolism genes. DOI: 10.1161/CIRCULATIONAHA.123.066542
• Wang XX et al. (2023) — The American Journal of Pathology — Reported that ERR agonism via SLU-PP-332 reversed mitochondrial dysfunction and reduced inflammation markers in an ageing kidney model. DOI: 10.1016/j.ajpath.2023.07.006
• Frontiers in Physiology (2025) — A pilot study examining SLU-PP-332 in primary myoblast cultures from inactive elderly subjects demonstrated reduced cellular senescence markers, increased PGC-1α expression, and improved myotube formation — supporting its relevance in age-related muscle atrophy research.Note: All cited studies are conducted in pre-clinical (in vitro and animal) models. No human clinical trials have been completed, and SLU-PP-332 is not approved for any human or medical use.

Is SLU-PP-332 the Same as an Exercise Pill?

This is one of the most frequently asked questions among researchers searching for SLU-PP-332 UK. In pre-clinical models, the compound demonstrated effects consistent with what scientists describe as an “exercise mimetic” — a compound that replicates specific molecular benefits of physical activity. Research from the University of Florida and Washington University described it as making the body act as if it were “training for a marathon,” with metabolic shifts toward fatty acid oxidation seen in both endurance exercise and fasted states.

However, SLU-PP-332 is a research compound only, has not been approved for human use, and all findings are from controlled laboratory and animal model studies. It is supplied strictly for in-vitro and pre-clinical research through Peptides Lab UK.

What is SLU-PP-332 Used For in Research?

Researchers purchasing SLU-PP-332 from UK peptides suppliers like Peptides Lab UK typically focus on:

• In vitro ERR receptor binding, activation, and selectivity studies
• Mitochondrial biogenesis and energy metabolism pathway investigations
• Obesity, metabolic syndrome, and type 2 diabetes pre-clinical models
• Structure–activity relationship (SAR) studies within the ERR agonist class
• Cardiovascular function and heart failure research
• Skeletal muscle endurance and fibre-type transition studies
• Comparative exercise mimetic research alongside GW501516 and AICAR
• Age-related metabolic decline, sarcopenia, and longevity pathway research

SLU-PP-332 UK – Purity & Quality Assurance

Every batch of SLU-PP-332 from Peptides Lab UK is:

• >99% pure — HPLC confirmed, third-party verified
• Supplied with a full Certificate of Analysis (COA) on request
• Manufactured under strict, controlled laboratory conditions
• Lyophilised for long-term stability and batch-to-batch consistency
• Trusted by researchers across the UK and Europe

Why Buy SLU-PP-332 from Peptides Lab UK?

As one of the UK’s most established research peptides suppliers, Peptides Lab UK offers:

• Third-party verified, HPLC-confirmed >99% purity on every batch
• Full batch documentation and Certificate of Analysis (COA) on request
• Fast dispatch from our UK-based facility
• Competitive pricing with bulk research discounts available
• Trusted by research professionals across the UK, Europe, and internationally

International Availability

You can also buy SLU-PP-332 in Ireland, buy SLU-PP-332 in Germany, buy SLU-PP-332 in France, buy SLU-PP-332 in the Netherlands, buy SLU-PP-332 in Spain, buy SLU-PP-332 in Italy, and across all EU member states — shipped directly from our UK peptides laboratory.

Looking to buy SLU-PP-332 in the UAE, buy SLU-PP-332 in Saudi Arabia (KSA), or elsewhere internationally? Peptides Lab UK ships globally with full customs documentation available on request.

Research Disclaimer: All products supplied by Peptides Lab UK are intended strictly for in-vitro laboratory research and scientific study use only. They are not intended for human consumption, veterinary use, or any medical application. SLU-PP-332 has not been evaluated by the MHRA or any regulatory authority for safety or efficacy in humans or animals. All research citations referenced on this page relate to pre-clinical and animal model studies and do not constitute evidence of safety or efficacy in humans. Peptides Lab UK accepts no liability for any misuse of research compounds. By purchasing, you confirm that you are a qualified researcher and that the product will be used solely within a controlled laboratory environment in compliance with all applicable laws and regulations.